Molecular Themes in Eukaryotic DNA Replication

This book tackles eukaryotic DNA replication from a novel perspective. Rather than simply itemising the steps in replication, and the proteins involved, it provides logical groupings of processes based on biochemical similarities. The very latest work on replication is highlighted with new insights into the process from pre-initiation through to termination. It also covers mitochondrial DNA replication, archaeal paradigms and exciting potential drug targets. The emphasis on mechanisms and the relationship between structure and function targets the book towards biochemists and biological chemists as well as cell biologists. Aimed at 'new-comers' and those more experienced, the style is learned but accessible. The chapters are written by internationally acclaimed researchers and rising stars in the field.

Lynne S Cox has worked in the field of eukaryotic DNA replication since 1987. Within three years of gaining her PhD, she was awarded a Royal Society of Edinburgh personal research fellowship to conduct her own independent research. During this time, she also ran a CRC-funded project examining replication control through an essential protein PCNA. She then took up a Fellowship at Oriel College, Oxford and a University Lectureship in the Department of Biochemistry at Oxford. As well as studying human DNA replication in relation to cancer and senescence, her laboratory’s work on malarial parasite replication factors more than doubled the number of characterized factors, with a view to developing inhibitors of malarial replication. Her most recent work has focussed on loss of replicative capacity during normal and accelerated human ageing, and she has recently secured funding to establish a Drosophila model for characterization of replicative senescence.